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Budd-Chiari syndrome

1 OMIM reference -
2 associated genes
20 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2

Cyclic neutropenia

1 OMIM reference -
1 associated gene
15 signs/symptoms

Budd-Chiari syndrome

Cyclic neutropenia

F5	(UniProt - OMIM)		ELANE	(UniProt - OMIM)
JAK2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	F5	(0.52)	ELANE

Citations in the biomedical literature:

Budd-Chiari syndrome		Cyclic neutropenia

	Classification (Orphanet): - Rare hepatic disease		Classification (Orphanet): - Rare genetic disease - Rare immune disease

	Classification (ICD10): - Diseases of the circulatory system -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: variable Average age of death: any age Type of inheritance: multigenic/multifactorial		Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: D006502		External references: 1 OMIM reference - 1 MeSH reference: C536227


COMMON SIGNS	- Acute abdominal pain / colic - Fever / chilling

Budd-Chiari syndrome		Cyclic neutropenia
	Very frequent - Ascitis - Portal hypertension - Splenomegaly Frequent - Abnormal hepatic enzymes / transaminases - Cirrhosis - Esophageal varices - Hepatocellular liver disease / hepatic failure - Hepatomegaly / liver enlargement (excluding storage disease) Occasional - Acute hepatic failure - Acute ischemic syndrome - Biliary / gallbladder stones / lithiasis / cholecystitis - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Hepatitis / icterus / cholestasis - Intestinal obstruction / ileus - Malabsorption / chronic diarrhea / steatorrhea - Mesenteric / intestinal infarction - Peritonitis / peritoneal abscess - Weight loss / loss of appetite / break in weight curve / general health alteration		Very frequent - Anaemia - Asthenia / fatigue / weakness - Chronic skin infection / ulcerations / ulcers / cancrum - Polynuclear cells / neutrophils anomalies / neutropenia - Sepsis severe / septicemia Frequent - Alveolysis / paraodontitis Occasional - Autosomal dominant inheritance - Enanthema / aphtosa / aphta / leukoplakia - Eosinophils anomalies / hypereosinophilia - Lymphadenopathy / polyadenopathies - Multiple caries - Repeat respiratory infections - Thrombocytopenia / thrombopenia